• kyonshi@piefed.social
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    7 hours ago

    Depends on the meds, and they can have a drastically different effect on people.

    Duloxetin: days, full effect after about a month (side effects after a year or so)
    Sertraline: never worked, in fact made stuff worse
    Prefaxine: about three weeks to feel noticeable effect.

  • nondescripthandle@lemmy.dbzer0.com
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    11 hours ago

    Define ‘working’ becsuse a lot of strife can come from the differences between what you’re expecting it to do and what will actually happen. For me, it just made it easier for me to lift myself out of bed in the morning and that’s about where the progress ends. And that’s the one I found after years of trying ones that were worse. They’re not happy pills, they just let you deal with the horrible shit instead of becoming immobilized by it.

  • GreatWhiteBuffalo41@slrpnk.net
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    16 hours ago

    Never. Turns out my issue was undiagnosed ADHD and trauma. Therapy and adderall have done wonders for me. I was trying to treat depression by itself, not as a side effect of another issue.

      • GreatWhiteBuffalo41@slrpnk.net
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        2 hours ago

        I’m not officially diagnosed autism but my doctor said I meet the criteria but didn’t want it written down due to the political climate.

    • massive_bereavement@fedia.io
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      15 hours ago

      Similar case for me, but I would recommend OP or anyone reading to work it through with their doctor (or even switch), being honest with them and oneself.

      • GreatWhiteBuffalo41@slrpnk.net
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        9 hours ago

        Yes exactly. It took me a few doctors to figure out what was going on because the first couple didn’t ask the questions that the doctor who diagnosed me did.

  • FollyDolly@lemmy.world
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    12 hours ago

    Zoloft, it took three days to start working. It had been an absolute gamechanger for my anxiety and I love it. 10/10

  • silspd@lemmy.world
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    17 hours ago

    Escitalopram took only one day for me. For both anxiety and depression.

    Bupropion took 3-4 weeks. For depression.

    Trintellix took about 2 weeks. For anxiety.

    • IlmariGanander@lemmy.wtf
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      3 hours ago

      Escitalopram fixed my Raynaud’s at a low “taper up” dose basically immediately. Although it wasn’t prescribed for that, this was just a happy side effect. I guess some SSRIs do that.

      For depression, it took about a month to ramp up enough to see a difference. It did ease the anhedonia, but it also masked my emotional flashbacks until it was too late to disrupt them.

      I also had SEVERE issues with my sodium while on it, which is why I didn’t stay on it past a month. However, I don’t snack or eat salty stuff so someone with higher sodium intake might have fared better.

      I would have tried to get used to it to see if the masking of the early signs of flashbacks got better as I got used to it if it hadn’t messed up my sodium so badly.

      Also, the sexual side effects are real.

  • Xaphanos@lemmy.world
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    18 hours ago

    Depression. Sertraline/Zoloft. Months.

    Initially, it helped a small amount. Possibly placebo. It was well-tolerated, so the dose was doubled. Then months (maybe 3?) of slight improvement.

    But when it really took hold it felt sudden.

  • AndyMFK@lemmy.dbzer0.com
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    17 hours ago

    They never worked. For some unlucky people, anti-depressants just straight up don’t work. If you’re new at it, keep at it, but if it’s been a few months it might be time to switch medication. if you’ve already switched a bunch of times, they might not work for you and your only option is probably therapy

      • 「黃家駒 Wong Ka Kui」@sh.itjust.worksOP
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        15 hours ago

        Seems to only mention SSRI specifically, not about antidepressants in general

        Also this: “suggested that the active ingredients in 10 of the most popularly prescribed antidepressant medications made a meaningful difference in only 15 percent of the patients who took them, almost always in those patients suffering from the most severe depression

        So yeah… that’s me lmfao…

  • towerful@programming.dev
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    21 hours ago

    Venlafaxine (SNRI).
    Took a couple weeks to settle into side effects, and about half a year to dial up the dosage (with side effects being a few days to a week after dosage changes).

    But it was pretty immediate. I think a big part was the act of treating it, the act of getting help.
    Had a lot of ups & downs, took a while to “trust” it, to recognise it working. And building the habit of taking meds helped maintain a schedule.

  • DaleGribble88@programming.dev
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    17 hours ago

    Anxiety meds typically a few days to start to notice. Depression meds either had severe negative side effects almost immediately, or positive effects would start showing up after 2 or 3 weeks.

  • mika_mika@lemmy.world
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    20 hours ago

    Months. It took months of my med schedule before I was like “maybe these are working”. My motivation and functioning was like zero still, but I wasn’t depressed anymore.

    Then doc put me back on a stimulant and it was so much more drastic an improvement I was frustrated we didn’t do that first.