• AndyMFK@lemmy.dbzer0.com
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    18 hours ago

    They never worked. For some unlucky people, anti-depressants just straight up don’t work. If you’re new at it, keep at it, but if it’s been a few months it might be time to switch medication. if you’ve already switched a bunch of times, they might not work for you and your only option is probably therapy

    • neaptide@lemmy.world
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      57 minutes ago

      There actually are other options for treatment-resistant depression, which is defined as depression that has little or no response to standard treatments like antidepressants.

      • Transcranial magnetic stimulation (TMS): uses magnetic currents to stimulate the brain while awake, typically provided 5x per week for 6 weeks (although there are now newer protocols that are much shorter in duration)
      • Ketamine: a general anesthetic drug typically provided via a nose spray 1-2 times per week for 8 weeks
      • Electroconvulsive therapy (ECT): uses electricity to induce a small seizure in the brain under sedation, typically provided 2-3 times per week for 3-4 weeks

      Source: https://www.mayoclinic.org/diseases-conditions/depression/in-depth/treatment-resistant-depression/art-20044324

      I try to spread the word about these treatments when I can because TMS helped me immensely after trying just about every antidepressant out there with no luck.

      • 「黃家駒 Wong Ka Kui」@sh.itjust.worksOP
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        16 hours ago

        Seems to only mention SSRI specifically, not about antidepressants in general

        Also this: “suggested that the active ingredients in 10 of the most popularly prescribed antidepressant medications made a meaningful difference in only 15 percent of the patients who took them, almost always in those patients suffering from the most severe depression

        So yeah… that’s me lmfao…