I mean, still what is significant? It seems you see the Napoleonic wars as such. Considering involvement of countries, the Crimean war had 4 great and 2 minor powers involved and lasted for 3 years. Granted the Crimean war was shorter and had less than the 6 great powers involved as were during the different coalition wars, with 1/4 the of the dead, but politically it was very significant and certainly not small nor regional in its effects.

That is factually incorrect, there have been many wars between the 1815 and 1914 that would qualify.

See the Crimean war 1853 or the German-French war 1870. With two or more great powers involved.

Or what is your definition?